Tamoxifen Tamoxifen, like clomiphene citrate, is an oral anti-estrogen compound that has been used to treat male infertility. The copulatory plug was absent or severely impaired in tamoxifen-treated males. Tamoxifen stimulates sperm output by increasing the release of gonadotropins. When mating experiments were performed, a significant decrease in the fertility index and increased percentages of preimplantation and postimplantation embryo loss were also observed. Finally, these alterations were capable of seriously compromising fertility ability of these male rats. Clomiphene usually is given in oral daily doses of mg for a 6 to 9-month period.
The effect of tamoxifen on spermatogenesis in subfertile men.
Compared with the placebo group, the relative risk of endometrial cancer among tamoxifen-treated women was 7. Priapism and suppression of spermatogenesis have been reported in male patients treated with tamoxifen. This study evaluates, compares, and contrasts the effects of three selective estrogen receptor modulators SERMs , namely, tamoxifen, toremifene, and raloxifene, on the hypothalamic-pituitary- testicular axis in consecutive subfertile men with idiopathic oligozoospermia using three therapeutic protocols: This study revealed that initial FSH values can be used as a marker to estimate the probability that a patient will benefit from oral TC therapy. In addition, tamoxifen has been reported to cause cataracts and other eye problems. Tamoxifen may cause blockages to form in a vein, lung, or brain.
Tamoxifen for Low Testosterone in Males - Jeffrey Dach MD
Although not all of these side effects may occur, if they do occur they may need medical attention. All patients received 20 mg TC daily as a single dose for 6 months, and semen analysis and hormone levels were analyzed after 6 months, with the values being compared with those before treatment. Along with its needed effects, a medicine may cause some unwanted effects. Fornander T, Hellstrom AC, Moberger B "Descriptive clinicopathologic study of 17 patients with endometrial cancer during or after adjuvant tamoxifen in early breast cancer. This may be due to tamoxifen-induced elevations in circulating thyroid binding globulin.
Tamoxifen Side Effects
Description: Several cases of keratopathy have also been reported. Coleman MP "Safety of tamoxifen. However, before drawing firm conclusions from this retrospective study, these results should be confirmed with double-blind, placebo-controlled, randomized trials. The benefits and timing of routine endometrial screening, after initial scrounge, have yet to be defined. Always consult your doctor or healthcare specialist for medical advice.